Chip-R1™ Rigid Chip
Improve precision in ADME and toxicology applications with a low-drug-absorption profile
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Catalogue No.
Chip-R1™ Rigid Chip
Improve precision in ADME and toxicology applications with a low-drug-absorption profile
Chip-R1™ Rigid Chip
Improve precision in ADME and toxicology applications with a low-drug-absorption profile
The Chip-R1 Rigid Chip is constructed with minimally drug-absorbing plastics, making it well suited for ADME and toxicology applications.
The minimally drug absorptive properties of Chip-R1’s rigid plastic make it better suited for ADME and toxicology applications, where being able to accurately calculate drug recovery is critical.
With up to 2.3 dyn/cm2 of shear stress, Chip-R1 increases physiological relevance for applications such as immune cell recruitment.
Chip-R1 features a pre-activated membrane, which streamlines the user workflow and saves time.
Imaging workflows are easier due to the significantly shorter working distance required to reach the epithelial channel.
Learn how Chip-R1 enables users to model organs without concern for drug absorption.
Absorption Profile of Hepatic-Relevant Compounds
Chip-R1 demonstrates a low-drug-absorbing profile for a panel of eight compounds with a range of physiochemical properties. Three of those compounds, including Nefazodone, are highly lipophilic compounds known to have high PDMS absorption liability. The Emulate Liver Quad Culture model on Chip-R1 was used to profile Nefazodone response in comparison to Chip-S1. Chip-R1 was able to detect a DILI response to Nefazodone that was absent on Chip-S1.
Average Compound Recovery Between 24–28 Hours of Flow.
Recovery refers to ratio of outlet to inlet concentration of concerned compound. Data shown as mean ± SD. Significance in recovery determined by two-way ANOVA with Fisher’s LSD multiple comparison test. n=3–4 chips per condition, with values for top and bottom channels averaged per chip, **p<0.01, ****p<0.0001.
Albumin Response
ALT Response
The Human Emulation System is comprised of instruments, consumables, and software in a flexible, open format. The user-friendly platform gives researchers a window into the inner workings of human biology.
Learn more about Chip-R1 and how it ensures greater accuracy for evaluating drug candidates, while building on key microfluidic capabilities.
