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Emulate Bio | Lymphoid Organ-Chip

Lymphoid Organ-Chip

Recapitulate human vaccine and adjuvant responses

The Lymphoid Organ-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support to build a Lymphoid Organ-Chip using the Human Emulation System.

Brand: Emulate Bio
SKU: Lymphoid Organ-Chip
Categories: Organ-on-a-Chip Technology, Organ-Chip Overview

In vivo-like lymph node functionality

The Lymphoid Organ-Chip model supports the formation of lymphoid follicles with functional germinal centers similar to those found in secondary and tertiary lymphoid organs in vivo, enabling researchers to recapitulate human vaccine and adjuvant responses.

3D Follicle Formation

Dynamic flow on-chip stimulates the assembly of large 3D multicellular aggregates.

Antigen-Specific Antibody Generation

Lymphoid Organ-Chips demonstrate significant anti-HA antibody generation following treatment with inactivated H5N1 virus.

Clinically Relevant Cytokine Production

The Lymphoid Organ-Chip displays clinically relevant levels of cytokines that are important for T cell expansion, survival, and helper functions.

Captures Donor-to-Donor Variability

Eight different human donors all produced anti-HA antibodies at detectable levels, with subsets of high and low responders identified.

Assess Responses to mRNA Vaccines

Myeloid cells capture and express mRNA vectored by lipid nanoparticles, enabling assessment of mRNA vaccines.

Neutralizing Antibody Production

Neutralizing antibody production against the SARS-CoV-2 spike protein has shown to be achieved after a culture duration of just six days.

The Lymphoid Organ-Chip design consists of a high-density 3D human PBMC culture within an ECM gel in the lower channel, while media and antigens are flowed in the upper channel of the chip.

The Lymphoid Organ-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support to build a Lymphoid Organ-Chip using the Human Emulation System.

Community Publication

Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ-on-a-Chip

Read this publication to learn how researchers at the Wyss Institute developed a human model of ectopic lymphoid follicle formation, offering a new tool for studying lymphoid follicle development and a promising alternative to non-human primates for preclinical vaccine evaluation. Learn More

Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting

In this publication, researchers from the Institut Pasteur demonstrate how the Lymphoid Organ-Chip model can be used for the preclinical evaluation of vaccine-boosting strategies. Learn More

3d Follicle formation

Media flow induces follicle formation in the Lymphoid Organ-Chip (Source: Advanced Science)

Antigen & Adjuvant Response

Vaccine and adjuvant-induced antibody production and follicle formation in the Lymphoid Organ-Chip. (Source: Advanced Science)

Clinically Relevant Cytokine Production

Lymphoid Organ-Chips show clinically relevant changes in cytokines 3 days after vaccination (C1-5) compared to unvaccinated chips. Changes observed in chips were similar to changes observed in the peripheral blood of 7 individuals (V1, 3, 4, 10–13) 1 day after vaccination as compared to their levels pre-vaccination (Source: Advanced Science)

Neutralizing Antibody Production

The Lymphoid Organ-Chip produced measurable neutralization of SARS-CoV-2 as early as day six for a subset of donors. (Source: Journal of Experimental Medicine)

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